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The Miracle Molecule

Dubbed "The Miracle Molecule," Alpha-2-Macroglobulin (A2M) is a powerful anti-inflammatory and protease inhibitor that can reduce pain and inflammation within 48-72 hours.

What does A2M have to do with Joint Pain?

APIC-A2M is a proprietary, patented therapy which concentrates Alpha-2-Macroglobulin (A2M). Therefore, it is different from other treatments. A naturally occurring molecule found in your blood, A2M when administered in concentrated doses, acts as a powerful protector against cartilage breakdown. The molecule attaches to and removes the destructive enzymes – proteases – which damage cartilage cells and tissues in the joint or disc space.

Alpha-2-Macroglobulin (A2M) "The Miracle Molecule"

Alpha-2-macroglobulin (A2M) has been called by some the “Miracle Molecule” for treating joint and back pain. It’s a naturally occurring molecule that is extracted from your own body, resulting in noninvasive, regenerative relief for joint diseases such as osteoarthritis.


Autologous Treament Therapy

A2M is a concentrated protein, harvested from your blood, that can help reduce inflammation and even stop the progression of degenerative arthritis. It is a great treatment for patients to have after a surgery or an injury that has caused swelling and inflammation. A2M reduces the risk of developing joint degeneration in the future. It can also be used to pretreat the joint before using stem cells. It dramatically reduces post-injection swelling and pain.

How Does Alpha2ACTIVE (A2M) Work?

The "Venus Flytrap"

A2M has two binding sites that capture proteases (E) like a venus flytrap.

Trap & Destroy

The molecule traps the proteases and breaks them down, flushing them out of the body through natural processes.

Watch an overview of the benefits of Alpha2ACTIVE Therapy


  • Improve Joint Function
  • Reduce Pain & Inflammation
  • Stop progression of osteoarthritis
  • Repair and restore joints
  • Move Better
  • Live Better

Expertise. Knowledge. Results.

The team behind The Regen Room is comprised of experts in regenerative medicine therapies, orthopedic surgery, sports medicine & primary care. Our areas of expertise include:


  • 8+ Years in Regenerative Medicine Therapies
  • 20+ Years in Orthopedic surgery
  • 20+ Years in Sports Medicine
  • 20+ Years in Chiropractic Medicine
  • Musculoskeletal Ultrasound
  • Physician Education and Training at:
    • Harvard Medical School
    • Baylor University
    • University of Oklahoma
    • Steadman Hawkins Clinic
    • Mayo Clinic

Some Pain Free Patients

After playing football my entire life and 9 years in the NFL, it eventually took a toll on my body. My shoulders and knees were a constant source of pain. I was very excited to try Alpha2ACTIVE after what I heard.

Honestly, I saw results within the first 24 hours in my shoulder. My mobility improved significantly. My the second and third days, I couldn’t believe how much better I felt in my knees. I was expecting some relief, but was really blown away at how much better I felt. And how quickly. I cannot say enough how much I recommend this for people suffering with joint pain. I highly recommend the Regen Room and Dr. Scott Waugh.

Kailee - Former NFL Football Player

“I am crying because I am so happy! Today is the first day in over 4 months that I could lift my left leg to get dressed. A2M is working!”

Hank B.

“I’ve tried other PRPs and had pain for weeks following injection. A2M made my shoulder pain disappear and NO pain after injection!”

Sylvia P.

"Pain free knees! Thanks to A2M Therapy!"

Ernest H.

"Thank you Dr. Scott Waugh! For many years I have suffered with arthritis, and still do. At 70, too many of my joints are causing me pain and great loss of power to use them. Stenosis of the spine and nerve issues are rising to bite me as well. One of the earliest joints to cause issues was my left knee. I’ve had numerous injections of various types. They are painful to receive, are expensive, and don’t last long. I had given up on them and just endure the occasional sharp pain. I work out at the YMCA and do my own yardwork and it’s the yardwork that seems to stress my knee the most. X-rays show bone fragments and bone spurs, and I believe the largest spur got bad enough to give me high levels of pain for several weeks. I needed “object support” to stand up from a sitting position.

In September 2018, Dr. Scott Waugh gave me an injection into my knee joint’s synovial fluid via ultrasound needle guidance. The substance was Exosomes on a Platelet-Rich Fibrin Matrix (PRFM). I got the injection about 4pm on a Saturday afternoon, propped the leg and took it easy for 24 hours. By Sunday afternoon I was walking pain free, faster than I was told to expect. I’ve had a few pains along the way, but it’s now Mid-January 2019 and I am generally pain free in my knee and have regained my physical activity. It’s sure beating the steroids and Hyaluronic Acid for me."

David L.

"My chronic knee pain is gone thanks to A2M!"

Joyce O.


  • Tell us where it hurts